Transcriptomics

Dataset Information

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Expression data from CD4-positive HTLV-positive cell lines and from CD4-positive HTLV-negative primary cells.


ABSTRACT: We used microarrays to compare the global programme of gene expression in HTLV-positive, ATL-derived and HTLV-positive in vitro-transformed cell lines with that of uninfected primary CD4 T cells. Cells were harvested one day after splitting, in case of primary T cells, cells were harvested after reaching a postmitotic state.

ORGANISM(S): Homo sapiens  

SUBMITTER: Ralph Grassmann   Andrea K Kress 

PROVIDER: E-GEOD-17718 | ArrayExpress | 2009-08-20

SECONDARY ACCESSION(S): GSE17718PRJNA118429

REPOSITORIES: GEO, ArrayExpress

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Publications

Elevated cyclic AMP levels in T lymphocytes transformed by human T-cell lymphotropic virus type 1.

Kress Andrea K AK   Schneider Grit G   Pichler Klemens K   Kalmer Martina M   Fleckenstein Bernhard B   Grassmann Ralph R  

Journal of virology 20100623 17


Human T-cell lymphotropic virus type 1 (HTLV-1), the cause of adult T-cell leukemia/lymphoma (ATLL), transforms CD4(+) T cells to permanent growth through its transactivator Tax. HTLV-1-transformed cells share phenotypic properties with memory and regulatory T cells (T-reg). Murine T-reg-mediated suppression employs elevated cyclic AMP (cAMP) levels as a key regulator. This led us to determine cAMP levels in HTLV-1-transformed cells. We found elevated cAMP concentrations as a consistent feature  ...[more]

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