Transcriptomics

Dataset Information

21

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer: DNA methylation


ABSTRACT: Methylation profiles of a panel of breast cancer lines that were included in the integrative analysis of DNA copy number, allelic status, DNA methylation and gene expression. Methylation profiles of 9 breast cancer cell lines and one normal line were generated. Genes were determined to be hyper and hypomethylation in a cell line with respect to the normal line, MCF10A.

ORGANISM(S): Homo sapiens  

SUBMITTER: Raj Chari   

PROVIDER: E-GEOD-17769 | ArrayExpress| 2014-05-02

SECONDARY ACCESSION(S): GSE17769PRJNA129039

REPOSITORIES: GEO, ArrayExpress

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Publications

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer.

Chari Raj R   Coe Bradley P BP   Vucic Emily A EA   Lockwood William W WW   Lam Wan L WL  

BMC systems biology 20100517


Genomics has substantially changed our approach to cancer research. Gene expression profiling, for example, has been utilized to delineate subtypes of cancer, and facilitated derivation of predictive and prognostic signatures. The emergence of technologies for the high resolution and genome-wide description of genetic and epigenetic features has enabled the identification of a multitude of causal DNA events in tumors. This has afforded the potential for large scale integration of genome and tran  ...[more]