Dataset Information


Expression data from B6C3F1 mice treated with reduced oxygen

ABSTRACT: Mice received decreasing oxygen concentrations from 21% to 6% O2 for ~ 30 minutes. Then, the mice remained an additional 120 minutes at 6% O2, control mice were placed insimilarchambers but recieved normal (21%) oxygen. Mice were euthanased by cervical dislocation under ketamine / acepromazine (100 mg/kg / 5 mg/kg, I.P) anesthesia. The bone marrow from the right humerus, a portion of the left lateral liver lobe and half a cross-section of the spleen were harvested and the RNA was isolated from these tissues using standard Qiagen reagents. Standard Affymetrix protocols were used for GeneChip probe preparations. 39 arrays.

ORGANISM(S): Mus musculus  

SUBMITTER: Petra Koza-Taylor   William Ladd 

PROVIDER: E-GEOD-17796 | ArrayExpress | 2010-01-10



altmetric image


To understand the molecular mechanisms underlying compound-induced hemangiosarcomas in mice, and therefore, their human relevance, a systems biology approach was undertaken using transcriptomics and Causal Network Modeling from mice treated with 2-butoxyethanol (2-BE). 2-BE is a hemolytic agent that induces hemangiosarcomas in mice. We hypothesized that the hemolysis induced by 2-BE would result in local tissue hypoxia, a well-documented trigger for endothelial cell proliferation leading to hema  ...[more]

Similar Datasets

2010-01-10 | E-GEOD-17794 | ArrayExpress
2010-01-11 | GSE17796 | GEO
2010-01-12 | E-GEOD-17266 | ArrayExpress
2010-01-11 | E-GEOD-17880 | ArrayExpress
2018-02-26 | E-MTAB-5741 | ArrayExpress
2010-01-11 | GSE17794 | GEO
2013-04-05 | E-GEOD-32100 | ArrayExpress
2009-01-22 | E-GEOD-11366 | ArrayExpress
2010-03-04 | E-GEOD-10870 | ArrayExpress
2011-01-31 | E-GEOD-24931 | ArrayExpress