Dataset Information


Transcription profiling of lung RNA from spontaneously hypertensive male rats after exposure to urban particulate matter (EHC-93)

ABSTRACT: We isolated total lung RNA from spontaneously hypertensive male rats 2–40 h after exposure to reference EHC-93. Three animals were exposed to EHC-93 in saline(10 mg/kg body weight) or saline at each time via intratracheal instillation or no instillation at all. RNA from different times was pooled for array hybridization as indicated.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Jeroen Pennings  

PROVIDER: E-GEOD-1796 | ArrayExpress | 2008-06-12



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Gene expression pattern in spontaneously hypertensive rats exposed to urban particulate matter (EHC-93).

Kooter I   Pennings J   Opperhuizen A   Cassee F  

Inhalation toxicology 20050101 1

Epidemiological studies show associations of short-term exposure to particulate matter with morbidity and mortality. Although many studies investigate the health effects of ambient particulate matter, the associated mechanisms, and the causality, they often focus on classical parameters. The objective of the present study was to gain insight into the roles of a wide range of genes in this process. Particular attention has been paid to immediate oxidative stress in the lung. We isolated total lun  ...[more]

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