Transcriptomics

Dataset Information

3

MiRNA expression data from human postnatal brain in prefrontal cortex: time course


ABSTRACT: Gene expression changes determine functional differentiation during development and are associated with functional decline during aging. While developmental changes are tightly regulated, regulation of aging changes is not well established. To assess the regulatory basis of age-related changes and investigate the mechanism of regulatory transition between development and aging, we measured mRNA and microRNA expression patterns in brains of humans and rhesus macaques over the entire species’ lifespan. We find that in both species, developmental and aging changes overlap in the course of lifetime with many changes found at the late age initiating in early childhood. Keywords: miRNA Age Series Keywords: Non-coding RNA profiling by high throughput sequencing Human post-mortem brain samples from the superior frontal gyrus region of the prefrontal cortex were collected. The age ranges of the indibiual in rhesus macaque covered the whole life span fom newborn to death.

ORGANISM(S): Homo sapiens  

SUBMITTER: Yuan Yuan   Song Guo  Philipp Khaitovich  Mehmet Somel  Zheng Yan  Haiyang Hu 

PROVIDER: E-GEOD-18012 | ArrayExpress | 2010-06-09

SECONDARY ACCESSION(S): GSE18012PRJNA123577

REPOSITORIES: GEO, ArrayExpress

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