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FIA plasma induces arthritis in naïve mice

ABSTRACT: Plasma collected from mice with FIA were pooled, and 0.3 ml was injected intravenously into 6-week-old naïve SJL mice on days 0 and 2. Synovial antigen array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B-cell responses against peptides representing native fibrinogen and citrullinated fibrinogen, and further epitope spreading resulting in additional targeting of fibronectin, collagen type V, cartilage gp39, and clusterin. Custom-spotted protein slides were probed with plasma samples from individual mice. Four slides were probed with plasma derived from naïve mice and four slides were probed with plasma derived from mice injected with FIA plasma.

ORGANISM(S): Mus musculus  

SUBMITTER: Maya J BenBarak   Lowen Y Lee  Peggy P Ho  Wolfgang Hueber  Orr Sharpe  Beren H Tomooka  Lawrence Steinman  William H Robinson  Xiaoyan Zhao  Piyanka E Chandra  William Robinson  Ricardo T Paniagua 

PROVIDER: E-GEOD-18024 | ArrayExpress | 2010-05-05



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Autoimmunity against fibrinogen mediates inflammatory arthritis in mice.

Ho Peggy P PP   Lee Lowen Y LY   Zhao Xiaoyan X   Tomooka Beren H BH   Paniagua Ricardo T RT   Sharpe Orr O   BenBarak Maya J MJ   Chandra Piyanka E PE   Hueber Wolfgang W   Steinman Lawrence L   Robinson William H WH  

Journal of immunology (Baltimore, Md. : 1950) 20091130 1

Rheumatoid arthritis (RA) is an autoimmune synovitis characterized by the presence of anticitrullinated protein Abs, although the exact targets and role of anticitrullinated protein autoimmunity in the pathogenesis of RA remain to be defined. Fibrinogen, which can be citrullinated, has recently emerged as a candidate autoantigen. To determine whether autoimmunity against fibrinogen can mediate inflammatory arthritis, we immunized a variety of common mouse strains with fibrinogen and found that D  ...[more]

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