Dataset Information


Mice with fibrinogen-induced arthritis (FIA)

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE18023: Mice with FIA develop anti-native and anti-in vitro citrullinated fibrinogen antibodies GSE18024: FIA plasma induces arthritis in naïve mice GSE18025: Fibrinogen-reactive T cells transfer disease to naïve mice Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: William Robinson  

PROVIDER: E-GEOD-18073 | ArrayExpress | 2010-05-05



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Autoimmunity against fibrinogen mediates inflammatory arthritis in mice.

Ho Peggy P PP   Lee Lowen Y LY   Zhao Xiaoyan X   Tomooka Beren H BH   Paniagua Ricardo T RT   Sharpe Orr O   BenBarak Maya J MJ   Chandra Piyanka E PE   Hueber Wolfgang W   Steinman Lawrence L   Robinson William H WH  

Journal of immunology (Baltimore, Md. : 1950) 20091130 1

Rheumatoid arthritis (RA) is an autoimmune synovitis characterized by the presence of anticitrullinated protein Abs, although the exact targets and role of anticitrullinated protein autoimmunity in the pathogenesis of RA remain to be defined. Fibrinogen, which can be citrullinated, has recently emerged as a candidate autoantigen. To determine whether autoimmunity against fibrinogen can mediate inflammatory arthritis, we immunized a variety of common mouse strains with fibrinogen and found that D  ...[more]

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