Transcriptomics

Dataset Information

5

COX-2 network as predictive molecular marker for clinical pregnancy in IVF


ABSTRACT: CONTEXT Nowadays, the molecular mechanisms involved in endometrial receptivity and implantation are still not clear. OBJECTIVE The gene expression of human endometrium of patients undergoing an IVF treatment with GnRH antagonists/rec-FSH was studied. CONCLUSIONS COX-2 has been extensively studied as a crucial fertility element in both knock-out mice and human. It appears that increased expression of COX-2 and/or SCGB1D2 on the day of oocyte retrieval in GnRH antagonist/rec-FSH stimulated cycles coincides with a lower probability of achieving a clinical pregnancy in this cycle. Keywords: gene expression analysis, clinical pregnancy in IVF stimulated cycles Endometrial biopsies taken from patients on day of oocyte retrieval in stimulated IVF cycles with 1 or 2 embryos replaced in the same cycle. Gene expression of pregnant patients (n=4) was compared with matched non-pregnant patients (n=4)

ORGANISM(S): Homo sapiens  

SUBMITTER: Human Fatemi   Peter In't Veld  Frans Schuit  Paul Devroey  Vanessa Ghislain  Claire Bourgain  Leentje Van Lommel  Inge Van Vaerenbergh 

PROVIDER: E-GEOD-18140 | ArrayExpress | 2010-09-06

SECONDARY ACCESSION(S): GSE18140PRJNA119429

REPOSITORIES: GEO, ArrayExpress

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Publications

Cyclooxygenase-2 network as predictive molecular marker for clinical pregnancy in in vitro fertilization.

Van Vaerenbergh Inge I   Blockeel Christophe C   Van Lommel Leentje L   Ghislain Vanessa V   In't Veld Peter P   Schuit Frans F   Fatemi Human Mousavi HM   Devroey Paul P   Bourgain Claire C  

Fertility and sterility 20100825 1


The gene expression of human endometrium on the day of oocyte retrieval of pregnant and nonpregnant patients in a stimulated IVF cycle was compared in two independent groups with different GnRH-antagonist ovarian stimulation protocols. The present data suggest that increased gene expression of cyclooxygenase-2, together with the expression of other molecules in the cyclooxygenase-2 network, on the day of oocyte retrieval in GnRH-antagonist cycles coincides with a lower probability of achieving a  ...[more]

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