Transcriptomics

Dataset Information

33

Transcription profiling by array of human, mouse and cow embryos


ABSTRACT: The process of early development of mammals is subtly and accurately controlled by the regulation networks of embryo cells. Time course expression data measured at different stages during early embryo development process can give us valuable information by revealing the dynamic expression patterns of genes in genome wide scale. In this study, bovine embryo expression data were generated at oocyte, one cell stage, two cell stage, four cell stage, eight cell stage, sixteen cell stage, morula, and blastocyst; Human embryo expression data were generated at one cell stage, two cell stage, four cell stage, eight cell stage, morula, and blastocyst; Mouse embryo expression data were generated at one cell stage, two cell stage, four cell stage, eight cell stage, morula, and blastocyst. Experiment Overall Design: Bovine, Human, and Mouse embryos were harvested at successive stage from oocyte to blastocyste. Total RNAs were extracted, amplified and hybridized onto Affymetrix microarrays.

SUBMITTER: Dan Xie  

PROVIDER: E-GEOD-18290 | ArrayExpress | 2009-10-02

SECONDARY ACCESSION(S): GSE18290PRJNA117925

REPOSITORIES: GEO, ArrayExpress

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Publications

Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species.

Xie Dan D   Chen Chieh-Chun CC   Ptaszek Leon M LM   Xiao Shu S   Cao Xiaoyi X   Fang Fang F   Ng Huck H HH   Lewin Harris A HA   Cowan Chad C   Zhong Sheng S  

Genome research 20100310 6


Mammalian preimplantation embryonic development (PED) is thought to be governed by highly conserved processes. While it had been suggested that some plasticity of conserved signaling networks exists among different mammalian species, it was not known to what extent modulation of the genomes and the regulatory proteins could "rewire" the gene regulatory networks (GRN) that control PED. We therefore generated global transcriptional profiles from three mammalian species (human, mouse, and bovine) a  ...[more]

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