Dataset Information


Transcription profiling of human intestinal cells (Caco-2) and tissues from all intestinal segments (duodenum, jejunum, ileum, colon)

ABSTRACT: Affymetrix U95Av2 expression data from human intestinal cells (Caco-2) and tissues from all intestinal segments (duodenum, jejunum, ileum, colon). Entries contain the search terms glycosylase, phosphorylase, cytochrome or nucleoside, which were relevant to our search for enzymes capable of cleaving the N-glycosidic bond of nucleoside analog drugs.

ORGANISM(S): Homo sapiens  

TISSUE(S): Jejunum, Duodenum, Colon, Ileum

SUBMITTER: Philip Larson Lorenzi  

PROVIDER: E-GEOD-1862 | ArrayExpress | 2007-06-21



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N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole.

Lorenzi Philip L PL   Landowski Christopher P CP   Brancale Andrea A   Song Xueqin X   Townsend Leroy B LB   Drach John C JC   Amidon Gordon L GL  

Drug metabolism and disposition: the biological fate of chemicals 20060324 6

The rapid in vivo degradation of the potent human cytomegalovirus inhibitor 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole (BDCRB) compared with a structural L-analog, maribavir (5,6-dichloro-2-(isopropylamino)-1-beta-L-ribofuranosyl-1H-benzimidazole), has been attributed to selective glycosidic bond cleavage. An enzyme responsible for this selective BDCRB degradation, however, has not been identified. Here, we report the identification of two enzymes, 8-oxoguanine DNA glycosylase (O  ...[more]

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