Transcriptomics

Dataset Information

4

Gene expression profile of bone marrow with post-irradiation radioprotector


ABSTRACT: To elucidate the mechanism of the in vivo radioprotection activity of Zn-containing heat-treated Saccharomyces cerevisiae yeast (Zn-yeast), expression changes in bone marrow after whole body irradiation (WBI) with concomitant treatment of Zn-yeast were analyzed using microarray technology. Keywords: mouse, bone marrow, Zn-containing heat-treated yeast administration, gamma-irradiation Zn-yeast suspension was administered i.p. into C3H mice immediately after 7.5 Gy WBI. Bone marrow from irradiated mice was extracted at 6 hours after irradiation and analyzed by microarray containing of 44,000 probes.

ORGANISM(S): Mus musculus  

SUBMITTER: Kaori Imadome   Mayumi Iwakawa 

PROVIDER: E-GEOD-18727 | ArrayExpress | 2010-09-27

SECONDARY ACCESSION(S): GSE18727PRJNA121629

REPOSITORIES: GEO, ArrayExpress

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Publications

Vascular homeostasis regulators, Edn1 and Agpt2, are upregulated as a protective effect of heat-treated zinc yeast in irradiated murine bone marrow.

Ueno Megumi M   Imadome Kaori K   Iwakawa Mayumi M   Anzai Kazunori K   Ikota Nobuo N   Imai Takashi T  

Journal of radiation research 20100101 5


PURPOSE:To elucidate the mechanism underlying the in vivo radioprotection activity by Zn-containing, heat-treated Saccharomyces cerevisiae yeast (Zn-yeast). MATERIALS AND METHODS:Zn-yeast suspension was administered into C3H/He mice immediately after whole body irradiation (WBI) at 7.5 Gy. Bone marrow was extracted from the mice 6 hours after irradiation and analyzed on a microarray. Expression changes in the candidate responsive genes differentially expressed in treated mice were re-examined by  ...[more]

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