Transcriptomics

Dataset Information

3

Effects of IGF 1 on primary breast fibroblasts, MCF-7 breast cancer cells and CCL-171 fibroblasts


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE18952: Effects of IGF 1 on primary breast fibroblasts (normal and carcinoma associated) GSE18953: Effects of IGF 1 on MCF-7 breast cancer cells GSE18954: Effects of IGF 1 on CCL-171 fibroblasts Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Michal Rajski  

PROVIDER: E-GEOD-18955 | ArrayExpress | 2010-06-24

SECONDARY ACCESSION(S): GSE18955PRJNA120989

REPOSITORIES: GEO, ArrayExpress

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Publications

IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients.

Rajski Michal M   Zanetti-Dällenbach Rosanna R   Vogel Brigitte B   Herrmann Richard R   Rochlitz Christoph C   Buess Martin M  

BMC Medicine 20100105


BACKGROUND: Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effects of IGF-I on cancer cells and stromal cells separately. METHODS: We used an ex vivo culture model and measured gene expression changes after IGF-I stimulation with cDNA microarrays. In vitro data were correlated with in vivo findings by comparing the results with published exp  ...[more]

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