Transcriptomics

Dataset Information

12

Transcription profiling by array of lung tissue from cardiac death and brain death donors, pre- and post-transplant


ABSTRACT: Lung donation after cardiac death (DCD), in contrast to donation after brain death (DBD), is a promising and increasingly common method to help relieve the shortage of donor organs. However, the pathogenetic consequences of retrieved lungs after DCD vs. DBD have not been clarified. We aimed to study the differential gene expression profiles in lungs of DCD and DBD patients. DCD patients were matched with DBD lung transplant cases from a prospectively maintained database. The number of tissue samples included in this study was 6 pre- and 5 post-transplant in DCD and 12 pre- and 12 post-transplant in DBD for a total number of 35 lung tissue samples.

REANALYSED by: E-GEOD-18995

ORGANISM(S): Homo sapiens  

SUBMITTER: Sina A Gharib   Masaki Anraku  Chang H Kang  Shaf Keshavjee  Jonathan Yeung  Marc de Perrot  Mingyao Liu  Marcelo Cypel  Tom W Waddell  Masaaki Sato  Andrew F Pierre  Chang-Hyun Kang 

PROVIDER: E-GEOD-18995 | ArrayExpress | 2009-11-11

SECONDARY ACCESSION(S): GSE18995PRJNA120663

REPOSITORIES: GEO, ArrayExpress

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Publications

Transcriptional signatures in donor lungs from donation after cardiac death vs after brain death: a functional pathway analysis.

Kang Chang Hyun CH   Anraku Masaki M   Cypel Marcelo M   Sato Masaaki M   Yeung Jonathan J   Gharib Sina A SA   Pierre Andrew F AF   de Perrot Marc M   Waddell Thomas K TK   Liu Mingyao M   Keshavjee Shaf S  

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20101118 3


BACKGROUND: Lung donation after cardiac death (DCD), in contrast to donation after brain death (DBD), is a promising and increasingly common method to help relieve the shortage of donor organs. We aimed to study the differential gene expression profiles in lungs of DCD and DBD patients and interpreted the differences using functional pathway analysis. METHODS: We performed microarray studies on pre- and post-transplant lung tissues from 7 DCD and 12 matched DBD patients. Gene profiling was perfo  ...[more]

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