Dataset Information


Effects of the Fnr homologue AadR on global gene expression

ABSTRACT: In order to define the AadR regulon we did transcriptome analysis of an aadR in frame-deletion mutant and compared to that of wild type. We found that AadR positively modulated expression of 43 genes, most of which are involved in degradation of aromatic acids under anaerobic conditions. It also activated expression of four genes encoding for unknown proteins and a possible DNA-binding stress protein. Furthermore, AadR repressed the expression of 100 genes, including fixK and many genes controlled by FixK, mainly those involved in a microaerobic lifestyle R. palustris strains were grown in defined medium anaerobically in light (photosynthetically) in sealed tubes with nitrogen gas in the headspace. Succinate and p-coumarate were provided as carbon sources.

ORGANISM(S): Rhodopseudomonas palustris  

SUBMITTER: Yasuhiro Oda   Caroline S Harwood  Federico E Rey 

PROVIDER: E-GEOD-19093 | ArrayExpress | 2010-12-13



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FixK, a global regulator of microaerobic growth, controls photosynthesis in Rhodopseudomonas palustris.

Rey Federico E FE   Harwood Caroline S CS  

Molecular microbiology 20100201 4

Purple non-sulphur phototrophic bacteria (PNSB) are excellent models for analysing the co-ordination of major metabolisms, including oxidative phosphorylation, photophosphorylation, carbon dioxide fixation and nitrogen fixation. In species studied to date, a two-component system called RegBA controls these functions and it has been thought that this redox sensing regulatory system is essential for co-ordinating electron flow and cannot be easily replaced. Here we show that this is not the case f  ...[more]

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