Dataset Information


Expression profiling of BORIS knockout mice testis

ABSTRACT: To identify differentially expressed genes in Boris KO testis, gene expression profilings were performed with NIAID mouse customized arrays. Gene expressions of five biological replicates of Boris KO testis were compared to those of wild type testis. Total RNAs from WT and BORIS KO testes prepared from P14 mice were labelled with Cy5 and Cy3, respectively. Five sets of each genotype were studied.

ORGANISM(S): Mus musculus  

SUBMITTER: Jeong-Heon Yoon   Teruhiko Suzuki  Elena Pugacheva  Natsuki Kosaka-Suzuki  Victor Lobanenkov  Dong-Mi Shin  Herbert C Morse  Ziedulla Abdullaev  Dmitri Loukinov  Svetlana Park 

PROVIDER: E-GEOD-19162 | ArrayExpress | 2010-06-05



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Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene BORIS.

Suzuki Teruhiko T   Kosaka-Suzuki Natsuki N   Pack Svetlana S   Shin Dong-Mi DM   Yoon Jeongheon J   Abdullaev Ziedulla Z   Pugacheva Elena E   Morse Herbert C HC   Loukinov Dmitri D   Lobanenkov Victor V  

Molecular and cellular biology 20100315 10

Previously, it was shown that the CTCF paralogous gene, BORIS (brother of the regulator of imprinted sites) is expressed in male germ cells, but its function in spermatogenesis has not been defined. To develop an understanding of the functional activities of BORIS, we generated BORIS knockout (KO) mice. Mice homozygous for the null allele had a defect in spermatogenesis that resulted in small testes associated with increased cell death. The defect was evident as early as postnatal day 21 and was  ...[more]

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