Transcriptomics

Dataset Information

4

Expression data of multiple sclerosis patients receiving Interferon-beta therapy


ABSTRACT: The purpose of this study was to characterize the transcriptional effects induced by intramuscular IFN-beta-1a treatment (Avonex, 30 µg once weekly) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 24 MS patients within the first four weeks of IFN-beta administration. Keywords: Multiple sclerosis, Interferon, Pharmacogenomics, Affymetrix EDTA blood samples were taken from all patients immediately before first, second and fifth IFN-beta injection. Total RNA of Ficoll-isolated peripheral blood mononuclear cells from each sample was extracted, labelled and hybridized to Affymetrix Human Genome U133 A and B arrays to quantify the mRNA levels.

ORGANISM(S): Homo sapiens  

SUBMITTER: Uwe K Zettl   Michael Hecker  Dirk Koczan  Robert H Goertsches 

PROVIDER: E-GEOD-19285 | ArrayExpress | 2010-05-19

SECONDARY ACCESSION(S): GSE19285PRJNA120367

REPOSITORIES: GEO, ArrayExpress

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