Transcriptomics

Dataset Information

4

Gene expression changes in mouse forebrain deficient in Dnmt1 and Dnmt3a


ABSTRACT: Two major DNA methylation-catalyzing enzymes, Dnmt1 and Dnmt3a, are expressed in postmitotic neurons, but their function in the adult central nervous system is unclear. We generated conditional mutant mice (CamKIIa Cre; Dnmt loxP) that lack either Dnmt1 or Dnmt3a, or both, exclusively in forebrain excitatory neurons and found only double-knockout (DKO) mice exhibited abnormal hippocampal CA1 long-term plasticity and deficits of learning and memory. DKO neurons also exhibit a significant up-regulation of immune genes, such as class I MHC and Stat1, which are implicated in synaptic plasticity. Four pairs of 2-3 month-old DKO and litter mate control were used. RNA samples were extracted from the cortex and hippocampus for gene expression array analysis.

ORGANISM(S): Mus musculus  

SUBMITTER: Jian Feng   jian feng  Guoping Fan 

PROVIDER: E-GEOD-19367 | ArrayExpress | 2010-12-03

SECONDARY ACCESSION(S): GSE19367PRJNA120407

REPOSITORIES: GEO, ArrayExpress

Similar Datasets

2010-12-03 | GSE19367 | GEO
2009-12-18 | E-GEOD-14216 | ArrayExpress
2011-12-01 | E-GEOD-23530 | ArrayExpress
2015-03-30 | E-GEOD-63280 | ArrayExpress
2015-08-03 | E-GEOD-58261 | ExpressionAtlas
2014-07-31 | E-GEOD-58261 | ArrayExpress
2014-08-19 | E-GEOD-50780 | ArrayExpress
2014-11-14 | E-GEOD-63273 | ArrayExpress
2012-12-31 | E-GEOD-38035 | ArrayExpress
| PRJNA267140 | ENA