Dataset Information


ETV1 knockdown in GIST cell lines

ABSTRACT: ETV1 is highly expressed in GIST cells and required for their survival and growth. To identify genes and pathways regulated by ETV1 in GIST, we performed expression profiles of GIST cells after ETV1 knockdown. Two GIST cell lines (GIST48 and GIST882) were infected in duplicate with three shRNA viruses (Scrambled, ETV1sh1-B11TRCN0000013923, ETV1sh2-TRCN0000013925). Four days after infection, RNA was harvested for expression profiling.

ORGANISM(S): Homo sapiens  

SUBMITTER: Yu Chen   C D Allis  Ping Chi  Charles L Sawyers 

PROVIDER: E-GEOD-19396 | ArrayExpress | 2010-10-13



altmetric image


Gastrointestinal stromal tumour (GIST) is the most common human sarcoma and is primarily defined by activating mutations in the KIT or PDGFRA receptor tyrosine kinases. KIT is highly expressed in interstitial cells of Cajal (ICCs)-the presumed cell of origin for GIST-as well as in haematopoietic stem cells, melanocytes, mast cells and germ cells. Yet, families harbouring germline activating KIT mutations and mice with knock-in Kit mutations almost exclusively develop ICC hyperplasia and GIST, su  ...[more]

Similar Datasets

2010-10-14 | E-GEOD-22852 | ArrayExpress
2013-05-10 | E-GEOD-46329 | ArrayExpress
2015-01-01 | S-EPMC4355391 | BioStudies
2010-01-01 | S-EPMC2955195 | BioStudies
2015-01-01 | E-GEOD-64608 | ArrayExpress
2013-01-01 | S-EPMC3776993 | BioStudies
2020-01-01 | S-EPMC7478956 | BioStudies
2013-01-01 | S-EPMC3747077 | BioStudies
2017-01-01 | S-EPMC5513719 | BioStudies
| GSE19396 | GEO