Transcriptomics

Dataset Information

64

ETV1 knockdown in GIST cell lines


ABSTRACT: ETV1 is highly expressed in GIST cells and required for their survival and growth. To identify genes and pathways regulated by ETV1 in GIST, we performed expression profiles of GIST cells after ETV1 knockdown. Two GIST cell lines (GIST48 and GIST882) were infected in duplicate with three shRNA viruses (Scrambled, ETV1sh1-B11TRCN0000013923, ETV1sh2-TRCN0000013925). Four days after infection, RNA was harvested for expression profiling.

ORGANISM(S): Homo sapiens  

SUBMITTER: Yu Chen   C D Allis  Ping Chi  Charles L Sawyers 

PROVIDER: E-GEOD-19396 | ArrayExpress | 2010-10-13

SECONDARY ACCESSION(S): GSE19396PRJNA129737

REPOSITORIES: GEO, ArrayExpress

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Publications


Gastrointestinal stromal tumour (GIST) is the most common human sarcoma and is primarily defined by activating mutations in the KIT or PDGFRA receptor tyrosine kinases. KIT is highly expressed in interstitial cells of Cajal (ICCs)-the presumed cell of origin for GIST-as well as in haematopoietic stem cells, melanocytes, mast cells and germ cells. Yet, families harbouring germline activating KIT mutations and mice with knock-in Kit mutations almost exclusively develop ICC hyperplasia and GIST, su  ...[more]

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