Transcriptomics

Dataset Information

8

Mental Retardation Patients


ABSTRACT: Profiling the genomic profiles of mental retardation patients. 13 mental retardation patients were selected for detection of genomic aberrations. Patient's DNA were hybridized against Promega control on Agilent G4426B arrays and scanned with the Agilent G2505B scanner.

ORGANISM(S): Homo sapiens  

SUBMITTER: frederic lepretre   Joris Andrieux  Frederic Lepretre 

PROVIDER: E-GEOD-19457 | ArrayExpress | 2010-05-18

SECONDARY ACCESSION(S): GSE19457PRJNA120323

REPOSITORIES: GEO, ArrayExpress

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Publications


Array-based comparative genomic hybridization (aCGH) is a powerful tool to detect genomic imbalances in the human genome. The analysis of aCGH data sets has revealed the existence of a widespread technical artifact termed as 'waves', characterized by an undulating data profile along the chromosome. Here, we describe the development of a novel noise-reduction algorithm, waves aCGH correction algorithm (WACA), based on GC content and fragment size correction. WACA efficiently removes the wave arti  ...[more]

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