Transcriptomics

Dataset Information

20

Limited systemic sclerosis patients with PAH show biomarkers of inflammation and vascular injury


ABSTRACT: Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury Forty-nine PBMC samples were obtained from 21 lSSc subjects without PAH (lSSc-noPAH), 15 lSSc subjects with PAH (lSSc-PAH), and 10 healthy controls; three subjects provided PBMCs one year later. Genome-wide gene expression was measured for each sample. Gene expression clearly distinguished lSSc samples from healthy controls, and separated lSSc-PAH from lSSc-NoPAH patients. The gene expression and cytokine profiles of lSSc-PAH patients suggest the presence of activated monocytes, and show markers of vascular injury and inflammation. Sample vs reference, total RNA isolated from peripheral blood mononuclear cells (PBMC), 21 lSSc subjects without PAH (lSSc-noPAH), 15 lSSc subjects with PAH (lSSc-PAH), and 10 healthy controls

ORGANISM(S): Homo sapiens  

SUBMITTER: Michael L Whitfield   Raphael Lemaire  Everett Hayes  Sarah A Pendergrass  Robert Lafyatis  Harrison W Farber  sarah a pendergrass  Giuseppina Farina 

PROVIDER: E-GEOD-19617 | ArrayExpress | 2010-10-27

SECONDARY ACCESSION(S): GSE19617PRJNA122567

REPOSITORIES: GEO, ArrayExpress

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Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury.

Pendergrass Sarah A SA   Hayes Everett E   Farina Giuseppina G   Lemaire Raphael R   Farber Harrison W HW   Whitfield Michael L ML   Lafyatis Robert R  

PloS one 20100817 8


Pulmonary arterial hypertension (PAH) is a common complication for individuals with limited systemic sclerosis (lSSc). The identification and characterization of biomarkers for lSSc-PAH should lead to less invasive screening, a better understanding of pathogenesis, and improved treatment.Forty-nine PBMC samples were obtained from 21 lSSc subjects without PAH (lSSc-noPAH), 15 lSSc subjects with PAH (lSSc-PAH), and 10 healthy controls; three subjects provided PBMCs one year later. Genome-wide gene  ...[more]

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