Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Danny Reinberg Manching Ku Bradley Bernstein
PROVIDER: E-GEOD-19708 | ArrayExpress | 2010-01-01
SECONDARY ACCESSION(S): GSE19708SRP001723PRJNA121895
REPOSITORIES: GEO, ArrayExpress, ENA
Genes & development 20100201 4
The Polycomb group proteins foster gene repression profiles required for proper development and unimpaired adulthood, and comprise the components of the Polycomb-Repressive Complex 2 (PRC2) including the histone H3 Lys 27 (H3K27) methyltransferase Ezh2. How mammalian PRC2 accesses chromatin is unclear. We found that Jarid2 associates with PRC2 and stimulates its enzymatic activity in vitro. Jarid2 contains a Jumonji C domain, but is devoid of detectable histone demethylase activity. Instead, its ...[more]