Dataset Information


Genes regulated by miR-145

ABSTRACT: We used Affymetrix HG U133 Plus 2.0 GeneChips to compare the transcriptome of miR-145-overexpressing MDA-MB-231 cells against negative control miRNA precursor-transfected cells. MDA-MB-231 cells were transfected with pre-miR-145 or a negative control pre-miRNA, and subsequently total RNA was collected and processed for analysis using Affymetrix microarrays. Three independent replicates were prepared for each comparison group.


ORGANISM(S): Homo sapiens  

SUBMITTER: George W Yip   Martin Götte 

PROVIDER: E-GEOD-19737 | ArrayExpress | 2010-09-07



altmetric image


miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness.

Götte M M   Mohr C C   Koo C-Y CY   Stock C C   Vaske A-K AK   Viola M M   Ibrahim S A SA   Peddibhotla S S   Teng Y H-F YH   Low J-Y JY   Ebnet K K   Kiesel L L   Yip G W GW  

Oncogene 20100906 50

Micro RNAs are small non-coding RNAs, which regulate fundamental cellular and developmental processes at the transcriptional and translational level. In breast cancer, miR-145 expression is downregulated compared with healthy control tissue. As several predicted targets of miR-145 potentially regulate cell motility, we aimed at investigating a potential role for miR-145 in breast cancer cell motility and invasiveness. Assisted by Affymetrix array technology, we demonstrate that overexpression of  ...[more]

Similar Datasets

2015-08-07 | E-GEOD-19737 | ExpressionAtlas
2010-09-07 | GSE19737 | GEO
2016-08-15 | E-GEOD-49962 | ArrayExpress
2013-08-01 | E-GEOD-23362 | ArrayExpress
2014-10-01 | E-GEOD-44139 | ArrayExpress
2014-06-15 | E-GEOD-58295 | ArrayExpress
2010-01-05 | GSE19717 | GEO
2010-01-26 | GSE20028 | GEO
2014-10-28 | PXD001260 | Pride
2010-03-05 | GSE20627 | GEO