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Expression data from human lymphoma endothelium and reactive lymph node-derived endothelium

ABSTRACT: Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc. Different gene expression profiles between lymphoma endothelium cells and reactive lymph node-derived endothelium cells may uncover these genes. And intensive mechanism researches on such key genes may explain the mechanisim of tumor-specific angiogenesis and help to explore effective treatment strategies to prevent/reverse tumor metastasis. We use microarrays to detail gene expression profiles of human lymphoma endothelium and reactive lymph node-derived endothelium. Lymph nodes were taken from surgery samples of cases pathologically diagnosed DLBCL (diffuse large B-cell lymphoma), PTL (peripheral T cell lymphoma) and reactive lymph nodes. The pure endothelium cells were isolated by LCM after immunohistochemical staining of CD34. We found Tim-3 was preferentially expressed on lymphoma-derived ECs via different expression profiles between lymphoma ECs and reactive lymph node-derived ECs. Intensive researches were carried out on Tim-3-expressing -ECs and we found that Tim-3 -expressing-Ecs may play important role on EC-mediated tumor evasion.

ORGANISM(S): Homo sapiens  

SUBMITTER: Xiangyang Bai   Yang Cao  Xiaoyuan Huang  ding ma 

PROVIDER: E-GEOD-19882 | ArrayExpress | 2010-01-14



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Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion.

Huang Xiaoyuan X   Bai Xiangyang X   Cao Yang Y   Wu Jingyi J   Huang Mei M   Tang Duozhuang D   Tao Si S   Zhu Tao T   Liu Yanling Y   Yang Yang Y   Zhou Xiaoxi X   Zhao Yanxia Y   Wu Mingfu M   Wei Juncheng J   Wang Daowen D   Xu Gang G   Wang Shixuan S   Ma Ding D   Zhou Jianfeng J  

The Journal of experimental medicine 20100222 3

Angiogenesis is increasingly recognized as an important prognosticator associated with the progression of lymphoma and as an attractive target for novel modalities. We report a previously unrecognized mechanism by which lymphoma endothelium facilitates the growth and dissemination of lymphoma by interacting with circulated T cells and suppresses the activation of CD4(+) T cells. Global gene expression profiles of microdissected endothelium from lymphoma and reactive lymph nodes revealed that T c  ...[more]

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