Transcriptomics

Dataset Information

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Transcriptional analysis of prefrontal area 9 in Parkinson's disease


ABSTRACT: Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects Published work contains more information on Parkinson and Control groups

REANALYSED by: E-GEOD-20168

OTHER RELATED OMICS DATASETS IN: E-GEOD-20292

ORGANISM(S): Homo sapiens  

SUBMITTER: Richard L Davis  Yanli Zhang   Frank A Middleton   Michael James    

PROVIDER: E-GEOD-20168 | ArrayExpress | 2010-02-22

SECONDARY ACCESSION(S): GSE20168PRJNA129811

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation.

Dumitriu Alexandra A   Latourelle Jeanne C JC   Hadzi Tiffany C TC   Pankratz Nathan N   Garza Dan D   Miller John P JP   Vance Jeffery M JM   Foroud Tatiana T   Beach Thomas G TG   Myers Richard H RH  

PLoS genetics 20120628 6


Parkinson disease (PD) is a complex neurodegenerative disorder with largely unknown genetic mechanisms. While the degeneration of dopaminergic neurons in PD mainly takes place in the substantia nigra pars compacta (SN) region, other brain areas, including the prefrontal cortex, develop Lewy bodies, the neuropathological hallmark of PD. We generated and analyzed expression data from the prefrontal cortex Brodmann Area 9 (BA9) of 27 PD and 26 control samples using the 44K One-Color Agilent 60-mer  ...[more]

Publication: 1/2

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