Transcriptomics

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Transcriptional analysis of multiple brain regions in Parkinson's disease


ABSTRACT: Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the following subset Series: GSE20168: Transcriptional analysis of prefrontal area 9 in Parkinson's disease GSE20291: Transcriptional analysis of putamen in Parkinson's disease GSE20292: Transcriptional analysis of whole substantia nigra in Parkinson's disease Refer to individual Series

OTHER RELATED OMICS DATASETS IN: E-GEOD-20168E-GEOD-20292

ORGANISM(S): Homo sapiens  

DISEASE(S): Control,Parkinson's Disease,Parkinsons Disease

SUBMITTER: Frank A Middleton   

PROVIDER: E-GEOD-20295 | ArrayExpress | 2010-03-23

SECONDARY ACCESSION(S): GSE20295PRJNA125325

REPOSITORIES: GEO, ArrayExpress

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Publications

Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms.

Zhang Yanli Y   James Michael M   Middleton Frank A FA   Davis Richard L RL  

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20050801 1


In both genetic and idiopathic forms of Parkinson's disease (PD), considerable evidence supports the involvement of alpha-synuclein, electron transport chain complex I, protein aggregation, and the ubiquitin-proteasome system. To investigate alterations in the transcription of genes that comprise these pathways, we performed gene expression profiling and functional gene group analysis of three brain regions (the substantia nigra, putamen, and area 9) in postmortem tissue from matched groups of P  ...[more]

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