Transcriptomics

Dataset Information

479

Analysis of small RNAs in piRNA pathway mutant mouse testes


ABSTRACT: Piwi-interacting RNAs are 25-32 nt small RNAs bound to Piwi proteins. To know the steps where factors involved in the piRNA biogenesis (MILI, MIWI2, ZUC (MitoPLD), MVH) work, we sequenced small RNAs from mutant mouse testes and analyzed piRNAs. Examination of small RNAs in testes of mutant mouse

ORGANISM(S): Mus musculus  

SUBMITTER: Yasushi Totoki   Hiroyuki Sasaki  Satomi Kuramochi-Miyagawa  Patrick J Murphy  Tatsuhiro Shibata  Asao Fujiyama  Naoko Iida  Kengo Gotoh  Paul D Soloway  Shinichiro Chuma  Toshiaki Watanabe  Takashi Sado  Kohzoh Mitsuya  Yasuhiro Yamamoto  Atsushi Toyoda  Yuko Hoki  Toru Nakano  Shin-ichi Tomizawa 

PROVIDER: E-GEOD-20327 | ArrayExpress | 2010-05-27

SECONDARY ACCESSION(S): SRP002253GSE20327PRJNA125393

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


MITOPLD is a member of the phospholipase D superfamily proteins conserved among diverse species. Zucchini (Zuc), the Drosophila homolog of MITOPLD, has been implicated in primary biogenesis of Piwi-interacting RNAs (piRNAs). By contrast, MITOPLD has been shown to hydrolyze cardiolipin in the outer membrane of mitochondria to generate phosphatidic acid, which is a signaling molecule. To assess whether the mammalian MITOPLD is involved in piRNA biogenesis, we generated Mitopld mutant mice. The mic  ...[more]

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