Transcriptomics,Multiomics

Dataset Information

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Transcription profiling of human breast cancer samples - relapse free survival


ABSTRACT: This series represents 180 lymph-node negative relapse free patients and 106 lymph-node negate patients that developed a distant metastasis. Please see attached patient clinical parameters sheet for more information (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?view=data&acc=GSE2034&id=40089&db=GeoDb_blob26). Keywords: other

OTHER RELATED OMICS DATASETS IN: E-GEOD-11324

ORGANISM(S): Homo sapiens  

DISEASE(S): Breast Cancer

SUBMITTER: Tim Jatkoe   

PROVIDER: E-GEOD-2034 | ArrayExpress | 2015-04-29

SECONDARY ACCESSION(S): GSE2034PRJNA91859

REPOSITORIES: GEO, ArrayExpress

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Publications


The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation, particularly in the case of estrogen-suppre  ...[more]

Publication: 1/2

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