Transcriptomics

Dataset Information

9

Transcription profiling of human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1)


ABSTRACT: Human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1).

ORGANISM(S): Homo sapiens  

TISSUE(S): Peripheral Blood Progenitor, Cord Blood

SUBMITTER: Agnes Viale  

PROVIDER: E-GEOD-2049 | ArrayExpress | 2007-08-30

SECONDARY ACCESSION(S): GSE2049GDS1074PRJNA91705

REPOSITORIES: GEO, ArrayExpress

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Publications

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.

Mulloy James C JC   Jankovic Vladimir V   Wunderlich Mark M   Delwel Ruud R   Cammenga Jorg J   Krejci Ondrej O   Zhao Hui H   Valk Peter J M PJ   Lowenberg Bob B   Nimer Stephen D SD  

Proceedings of the National Academy of Sciences of the United States of America 20050224 11


The AML1-ETO fusion protein, generated by the t(8;21) in acute myeloid leukemia (AML), exerts dominant-negative functions and a variety of gains of function, including a positive effect on the growth of primary human CD34+ hematopoietic stem/progenitor cells. We now show that AML1-ETO expression up-regulates the level of TRKA mRNA and protein in these cells and that AML1-ETO-expressing CD34+ hematopoietic cells grown in the presence of five early-acting hematopoietic cytokines further proliferat  ...[more]

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