Transcriptomics

Dataset Information

4

Gene expression analysis of leukemic samples in C57BL6 mice


ABSTRACT: [original title] Gene expression analysis of leukemic samples derived from AF4-MLL- or AF4-MLL/MLL-AF4-transduced and transplanted hematopoietic stem/precursor cells in C57BL6 mice. We used microarrays to analyze the global gene expression in leukemic cells with three distinct immunophenotypes. We compared leukemic cells isolated from the bone marrow of diseased mice and compared these profiles with normal bone marrow.

ORGANISM(S): Mus musculus  

SUBMITTER: L Klein-Hitpass   Rolf Marschalek 

PROVIDER: E-GEOD-20519 | ArrayExpress | 2010-07-07

SECONDARY ACCESSION(S): GSE20519PRJNA125245

REPOSITORIES: GEO, ArrayExpress

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Publications

The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

Bursen Adelheid A   Schwabe Karen K   Rüster Brigitte B   Henschler Reinhard R   Ruthardt Martin M   Dingermann Theo T   Marschalek Rolf R  

Blood 20100301 17


The chromosomal translocation t(4;11)(q21;q23) is the most frequent genetic aberration of the human MLL gene, resulting in high-risk acute lymphoblastic leukemia (ALL). To elucidate the leukemogenic potential of the fusion proteins MLL.AF4 and AF4.MLL, Lin(-)/Sca1(+) purified cells (LSPCs) were retrovirally transduced with either both fusion genes or with MLL.AF4 or AF4.MLL alone. Recipients of AF4.MLL- or double-transduced LSPCs developed pro-B ALL, B/T biphenotypic acute leukemia, or mixed lin  ...[more]

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