Transcriptomics

Dataset Information

0

MicroRNA miR-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts


ABSTRACT: This is the first report to document circadian rhythmicity of specific microRNAs in rat jejunum. Our data provide a link between the anti-proliferative microRNA miR-16 and the intestinal proliferation rhythm and point to miR-16 as an important regulator of proliferation in jejunal crypts. This function may be essential to match proliferation and absorptive capacity with nutrient availability. Time course data with 7 time points and 3 replicates per time point. Each 2-color array is hybridized against a reference from time point 0, and dye swaps are included.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Jonathan M Dreyfuss  

PROVIDER: E-GEOD-20603 | ArrayExpress | 2010-08-13

SECONDARY ACCESSION(S): GSE20603PRJNA124775

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

MicroRNA mir-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts.

Balakrishnan Anita A   Stearns Adam T AT   Park Peter J PJ   Dreyfuss Jonathan M JM   Ashley Stanley W SW   Rhoads David B DB   Tavakkolizadeh Ali A  

Experimental cell research 20100713 20


The intestine exhibits profound diurnal rhythms in function and morphology, in part due to changes in enterocyte proliferation. The regulatory mechanisms behind these rhythms remain largely unknown. We hypothesized that microRNAs are involved in mediating these rhythms, and studied the role of microRNAs specifically in modulating intestinal proliferation.Diurnal rhythmicity of microRNAs in rat jejunum was analyzed by microarrays and validated by qPCR. Temporal expression of diurnally rhythmic mi  ...[more]

Similar Datasets

2010-05-26 | E-GEOD-10602 | ArrayExpress
2010-04-28 | E-GEOD-21346 | ArrayExpress
2014-06-15 | E-GEOD-54692 | ArrayExpress
2014-06-10 | E-GEOD-55515 | ArrayExpress
2010-08-13 | GSE20603 | GEO
2012-12-20 | E-GEOD-39486 | ArrayExpress
2017-10-28 | E-MTAB-6052 | ArrayExpress
2012-10-13 | E-GEOD-41537 | ArrayExpress
2010-04-09 | E-GEOD-15925 | ArrayExpress
2012-05-02 | E-GEOD-37036 | ArrayExpress