Transcriptomics

Dataset Information

43

Breast Carcinomas arising at a Young Age: A Unique Biology or a Surrogate for Aggressive Intrinsic Subtypes.


ABSTRACT: Breast cancer is no longer viewed as a homogenous disease, but rather a compilation of several distinct subtypes as defined by microarray or other large scale genomic analyses. Based on prior reports, we hypothesized that younger women’s breast tumors would be enriched for more aggressive subtypes (i.e. Basal-like) and higher grade, and that age-specific gene expression differences may be highly dependent on subtype classification and/or grade. Using two independent datasets, our current analysis shows that breast tumors arising in women aged = 45 years are enriched for the Basal-like subtype (and higher grade) while those aged = 65 years are enriched for Luminal tumors. Moreover, when evaluating gene expression differences between age-defined groups, sizable gene lists were identified which diminished to few, if any, age-specific genes when statistically correcting for significant clinical factors (i.e. subtype, grade, etc). Keywords: reference x sample 344 breast tumor samples hybridized with Stratagene common reference and profiled on Agilent microarrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Charles Perou  Charles M Perou   Carey K Anders    

PROVIDER: E-GEOD-20624 | ArrayExpress| 2014-05-01

SECONDARY ACCESSION(S): GSE20624PRJNA124813

REPOSITORIES: GEO, ArrayExpress

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Publications

Breast carcinomas arising at a young age: unique biology or a surrogate for aggressive intrinsic subtypes?

Anders Carey K CK   Fan Cheng C   Parker Joel S JS   Carey Lisa A LA   Blackwell Kimberly L KL   Klauber-DeMore Nancy N   Perou Charles M CM  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101129 1


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