Transcriptomics

Dataset Information

123

Expression profiling of human adipose stromal cell (hASC) adipogenesis


ABSTRACT: Human abdominal adipose tissue was obtained with informed consent from a 33-year old Caucasian female (BMI = 32.96 Kg/m2) undergoing lipoaspiration. Adipose stromal cells (hASCs) were isolated and differentiated into adipocytes in vitro. Two technical replicates from 9 time points realtive to induction of adipogenesis (day 0). Also, two technical replicated from pre-adipocytes (day -2) grown without FGF. Two individual replicates (day 1 and day 7) were removed due to failed hybridizations.

ORGANISM(S): Homo sapiens  

SUBMITTER: Tarjei S Mikkelsen   Zhao Xu  Evan D Rosen  Jeffery M Gimble  Eric S Lander 

PROVIDER: E-GEOD-20697 | ArrayExpress | 2010-09-30

SECONDARY ACCESSION(S): GSE20697PRJNA129563

REPOSITORIES: GEO, ArrayExpress

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Publications

Comparative epigenomic analysis of murine and human adipogenesis.

Mikkelsen Tarjei S TS   Xu Zhao Z   Zhang Xiaolan X   Wang Li L   Gimble Jeffrey M JM   Lander Eric S ES   Rosen Evan D ED  

Cell 20101001 1


We report the generation and comparative analysis of genome-wide chromatin state maps, PPARγ and CTCF localization maps, and gene expression profiles from murine and human models of adipogenesis. The data provide high-resolution views of chromatin remodeling during cellular differentiation and allow identification of thousands of putative preadipocyte- and adipocyte-specific cis-regulatory elements based on dynamic chromatin signatures. We find that the specific locations of most such elements d  ...[more]

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