Dataset Information


Hepatic gene expression profiling reveals key pathways involved in leptin mediated weight loss in ob/ob mice.

ABSTRACT: The purpose of this study was to identify leptin target genes and subsequent pathways correlated with leptin-mediated weight loss. We utilized the microarray technology to compare two types of leptin administration: one involving a direct stimulatory effect when administered peripherally (subcutaneous: SQ) and another that is indirect, involving a hypothalamic relay that suppresses food intake when leptin is administered centrally (intracerebroventricular: ICV). We report here the impact of central and peripheral administration of leptin on food intake, body weight and body fat composition in ob/ob mice. We also report hepatic gene expression changes caused by central versus peripheral leptin administration. Keywords: comparison Leptin deficient (ob/ob) mice were continuously administered leptin over 12-days using central (intracerebroventricular) or peripheral (subcutaneous) route of administration. Liver RNA was extracted and hybridized to Illumina microarrays and gene expression data was analyzed. The global gene expression profiles were compared after the central and peripheral leptin treatments in ob/ob mice and C57BL6 mice were used for the baseline gene expression.

ORGANISM(S): Mus musculus  

SUBMITTER: Ashok Sharma   Jin-Xiong She  Clifton Baile  Bo Chen  Richard McIndoe  Shoshana Bartell  Robert Podolsky 

PROVIDER: E-GEOD-20878 | ArrayExpress | 2010-11-10



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