Dataset Information


Comparative Gene Expression Profiling of HUVEC and Ocular Vascular Endothelial Cells

ABSTRACT: To compare the gene expression profiles of unpassaged, proliferating HUVEC and human iris, retinal and choroidal microvascular endothelial cells. Gene expression profiling revealed significant differences between HUVEC and ocular microvascular endothelial cells suggesting that HUVE cells may not be a suitable surrogate when studying pathophysiological mechanisms of ocular disorders. There were significant differences in the gene expression of important cell signalling pathways in human retinal and choroidal ECs. These differences may be important in the mechanisms and treatment of choroidal and retinal neovascularisation. 12 arrays are included. Endothelial cells were derived from 4 tissues: iris, retina, choroid and human umbilical vein. RNA extracts from cells were hybridised to Affymetrix HGU133plus2 arrays in triplicate.

ORGANISM(S): Homo sapiens  

SUBMITTER: Daniel Swan   Andrew C Browning  Daniel C Swan 

PROVIDER: E-GEOD-20986 | ArrayExpress | 2010-12-31



Similar Datasets

2010-12-31 | GSE20986 | GEO
2013-12-31 | E-GEOD-51246 | ArrayExpress
2018-03-26 | PXD005972 | Pride
2008-06-13 | E-GEOD-5134 | ArrayExpress
2008-06-15 | E-GEOD-7850 | ArrayExpress
2007-05-25 | GSE7850 | GEO
2012-05-10 | E-GEOD-37898 | ArrayExpress
2017-02-23 | E-MTAB-5535 | ArrayExpress
2009-05-01 | GSE15566 | GEO
| GSE27238 | GEO