Dataset Information


NF1 inactivation in adult acute myelogenous leukemia

ABSTRACT: Purpose: This study was conducted to identify novel genes with importance to the biology of adult acute myelogenous leukemia (AML). Conclusions: NF1 null states are present in 7/95=7% of adult AML and delineate a disease subset that could be preferentially targeted by Ras or mTOR-directed therapeutics. Experimental design: We analyzed DNA from highly purified AML blasts and paired buccal cells from 95 patients for recurrent genomic microdeletions using ultra-high density Affymetrix SNP 6.0 array-based genomic profiling. 006, 096 and 136 normal Samples have been excluded from study.

ORGANISM(S): Homo sapiens  

SUBMITTER: Peter Ouillette   Brian Parkin  Judith Karp  Sami N Malek  Diane Roulston  Cheng Li  Paula Bockenstedt  Yang Liu  Harry Erba  Sajid Shakhan  Kerby Shedden  Yan Liu  Anjali Purkayastha  Lisa Kujawski  Yin Wang  Amanda Dressel  Ammar Al-Zoubi  Whitney Wright  Moshe Talpaz  Sami N Malek 

PROVIDER: E-GEOD-21107 | ArrayExpress | 2010-12-02



Similar Datasets

2015-03-01 | E-GEOD-61323 | ArrayExpress
2013-02-12 | E-GEOD-41646 | ArrayExpress
2007-08-30 | E-GEOD-2049 | ArrayExpress
2016-07-01 | E-GEOD-78076 | ArrayExpress
2016-07-27 | E-GEOD-84849 | ArrayExpress
2015-03-05 | E-GEOD-66529 | ArrayExpress
2015-04-21 | E-GEOD-57761 | ArrayExpress
2010-02-19 | E-TABM-909 | ArrayExpress
2011-12-01 | E-GEOD-34044 | ArrayExpress
2018-07-06 | E-MTAB-6831 | ArrayExpress