Transcriptomics

Dataset Information

5

NF1 inactivation in adult acute myelogenous leukemia


ABSTRACT: Purpose: This study was conducted to identify novel genes with importance to the biology of adult acute myelogenous leukemia (AML). Conclusions: NF1 null states are present in 7/95=7% of adult AML and delineate a disease subset that could be preferentially targeted by Ras or mTOR-directed therapeutics. Experimental design: We analyzed DNA from highly purified AML blasts and paired buccal cells from 95 patients for recurrent genomic microdeletions using ultra-high density Affymetrix SNP 6.0 array-based genomic profiling. 006, 096 and 136 normal Samples have been excluded from study.

ORGANISM(S): Homo sapiens  

SUBMITTER: Peter Ouillette   Brian Parkin  Judith Karp  Sami N Malek  Diane Roulston  Cheng Li  Paula Bockenstedt  Yang Liu  Harry Erba  Sajid Shakhan  Kerby Shedden  Yan Liu  Anjali Purkayastha  Lisa Kujawski  Yin Wang  Amanda Dressel  Ammar Al-Zoubi  Whitney Wright  Moshe Talpaz  Sami N Malek 

PROVIDER: E-GEOD-21107 | ArrayExpress | 2010-12-02

SECONDARY ACCESSION(S): GSE21107PRJNA126677

REPOSITORIES: GEO, ArrayExpress

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