Transcriptomics

Dataset Information

4

Screen differential expressed microRNAs of RA patients


ABSTRACT: We screened the differential expressed microRNA from the rheumatoid arthritis patients and healthy person in their hydrops articuli CD4+ T cells. We screened the differential expressed microRNA from the rheumatoid arthritis patients and healthy person in their hydrops articuli CD4+ T cells. 1.Isolated the CD4+ T cells from the hydrops articuli cells of 2 rheumatoid arthritis patients. 2.Isolated the CD4+ T cells from healthy person's peripheral blood as control. 3.Isolation of total RNA from CD4+ T cells then sent the samples to KangChen Bio-tech Inc (Shanghai, China) where they were labeled, hybridized, scaned, normalied and transformed to the final data.

ORGANISM(S): Homo sapiens  

SUBMITTER: jingyi li  

PROVIDER: E-GEOD-21118 | ArrayExpress | 2010-04-03

SECONDARY ACCESSION(S): GSE21118PRJNA126473

REPOSITORIES: GEO, ArrayExpress

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Publications

Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis.

Li Jingyi J   Wan Ying Y   Guo Qiuye Q   Zou Liyun L   Zhang Jinyu J   Fang Yongfei Y   Zhang Jingbo J   Zhang Jinjun J   Fu Xiaolan X   Liu Hongli H   Lu Liwei L   Wu Yuzhang Y  

Arthritis Research & Therapy 20100511 3


INTRODUCTION: Increasing evidence indicates that microRNAs (miRNAs) play a critical role in the pathogenesis of inflammatory diseases. The aim of the study was to investigate the expression pattern and function of miRNAs in CD4+ T cells from patients with rheumatoid arthritis (RA). METHODS: The expression profile of miRNAs in CD4+ T cells from synovial fluid (SF) and peripheral blood of 33 RA patients was determined by microarray assay and validated by qRT-PCR analysis. The correlation between a  ...[more]

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