Transcriptomics

Dataset Information

6

Transcription profiling of rat left ventricular samples from 12-, 16- and 20-month old spontaneously hypertensive rats (SHRs) compared with age-matched Wistar-Kyoto (WKY) rats as controls


ABSTRACT: Left ventricular gene expression profiles from 12-, 16- and 20-months old spontaneously hypertensive rats (SHRs) were compared with left ventricular profiles seen in age-matched Wistar-Kyoto (WKY) rats [control rats] by screening Affymetrix U34A arrays (there are 4 samples in each timepoint except 3 samples of 20-months old WKYs).

REANALYSED by: E-GEOD-2116

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Jaana Rysä  

PROVIDER: E-GEOD-2116 | ArrayExpress | 2007-09-20

SECONDARY ACCESSION(S): GDS1264GSE2116PRJNA91775

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Distinct upregulation of extracellular matrix genes in transition from hypertrophy to hypertensive heart failure.

Rysä Jaana J   Leskinen Hanna H   Ilves Mika M   Ruskoaho Heikki H  

Hypertension (Dallas, Tex. : 1979) 20050418 5


Cardiac hypertrophy in response to pressure overload is initially beneficial but eventually leads to heart failure, a major cause of morbidity and mortality in the Western countries. Although abnormalities in left ventricular (LV) diastolic filling are early features associated with pressure overload-induced LV hypertrophy, the molecular mechanisms regulating transition to diastolic heart failure are poorly understood. We analyzed global changes in gene expression in 12-, 16-, and 20-month-old s  ...[more]

Similar Datasets

2014-08-15 | E-GEOD-2116 | ExpressionAtlas
2005-07-01 | GSE2116 | GEO
2006-07-05 | GSE2876 | GEO
2012-04-30 | E-GEOD-35088 | ArrayExpress
2006-08-31 | E-MEXP-357 | ArrayExpress
2013-11-15 | E-GEOD-47495 | ArrayExpress
2007-11-01 | E-GEOD-1675 | ArrayExpress
2015-04-15 | E-GEOD-67874 | ArrayExpress
2016-09-01 | E-GEOD-73387 | ArrayExpress
2016-07-03 | E-MTAB-3831 | ArrayExpress