Transcriptomics

Dataset Information

3

Differential methylation profiling of colon tumors


ABSTRACT: Differential methylation profiling of 18 colon tumor samples vs normal colon mucosa using the LogRatios of samples/reference panel 18 colon tumors and 8 normal mucosa

ORGANISM(S): Homo sapiens  

SUBMITTER: Eddy H van Roon   Judith M Boer  Eddy H.J. van Roon 

PROVIDER: E-GEOD-21181 | ArrayExpress | 2011-02-07

SECONDARY ACCESSION(S): GSE21181PRJNA126549

REPOSITORIES: GEO, ArrayExpress

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Publications

Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer.

van Roon Eddy H J EH   de Miranda Noël F C C NF   van Nieuwenhuizen Merlijn P MP   de Meijer Emile J EJ   van Puijenbroek Marjo M   Yan Pearlly S PS   Huang Tim H-M TH   van Wezel Tom T   Morreau Hans H   Boer Judith M JM  

European journal of human genetics : EJHG 20101208 3


DNA methylation is a hallmark in a subset of right-sided colorectal cancers. Methylation-based screening may improve prevention and survival rate for this type of cancer, which is often clinically asymptomatic in the early stages. We aimed to discover prognostic or diagnostic biomarkers for colon cancer by comparing DNA methylation profiles of right-sided colon tumours and paired normal colon mucosa using an 8.5 k CpG island microarray. We identified a diagnostic CpG-rich region, located in the  ...[more]

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