Transcriptomics

Dataset Information

62

Peroxisomes are signaling patforms for antiviral innate immunity


ABSTRACT: Analysis of the transcriptional response of mouse embryonic fibroblasts to reovirus infection. The hypothesis tested was that both peroxisomal and mitochondrial MAVS is capable of inducing the expression of antiviral genes. mRNA isolated from MAVS-expressing cells after infection for various times with reovirus

ORGANISM(S): Mus musculus  

SUBMITTER: Jonathan Kagan   Evelyn Dixit  Jonathan C Kagan 

PROVIDER: E-GEOD-21215 | ArrayExpress | 2010-11-04

SECONDARY ACCESSION(S): GSE21215PRJNA126311

REPOSITORIES: GEO, ArrayExpress

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Publications


Peroxisomes have long been established to play a central role in regulating various metabolic activities in mammalian cells. These organelles act in concert with mitochondria to control the metabolism of lipids and reactive oxygen species. However, while mitochondria have emerged as an important site of antiviral signal transduction, a role for peroxisomes in immune defense is unknown. Here, we report that the RIG-I-like receptor (RLR) adaptor protein MAVS is located on peroxisomes and mitochond  ...[more]

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