Dataset Information


Expression data from an ASCL1 siRNA experiment

ABSTRACT: To elucidate whether or not a subtype of adenocarcinoma with neuroendocrine nature has poor prognosis, we performed gene expression profiling of an achaete-scute complex homolog 1 (ASCL1) siRNA experiment. siRNA againt ASCL1 was transfected into DMS79 cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: T Fujiwara  

PROVIDER: E-GEOD-21216 | ArrayExpress | 2011-07-18



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ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis.

Fujiwara Takeshi T   Hiramatsu Miyako M   Isagawa Takayuki T   Ninomiya Hironori H   Inamura Kentaro K   Ishikawa Shumpei S   Ushijima Masaru M   Matsuura Masaaki M   Jones Michael H MH   Shimane Miyuki M   Nomura Hitoshi H   Ishikawa Yuichi Y   Aburatani Hiroyuki H  

Lung cancer (Amsterdam, Netherlands) 20110706 1

BACKGROUND:Lung adenocarcinoma is heterogeneous regarding histology, etiology and prognosis. Although there have been several attempts to find a subgroup with poor prognosis, it is unclear whether or not adenocarcinoma with neuroendocrine (NE) nature has unfavorable prognosis. MATERIALS AND METHODS:To elucidate whether a subtype of adenocarcinoma with NE nature has poor prognosis, we performed gene expression profiling by cDNA microarray for 262 Japanese lung cancer and 30 normal lung samples, i  ...[more]

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