Transcriptomics

Dataset Information

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Profiling wt SOD versus ALS SOD1(G93A) mutant


ABSTRACT: Whole-genome profiling of SH-SY5Y cells was done on neuroblastoma SH-SY5Y stably transfected with cDNAs coding for SOD1WT or the mutant SOD1(G93A) protein. Five wt SOD versus five mutant SOD

ORGANISM(S): Homo sapiens  

SUBMITTER: Mauro Cozzolino   Tilmann Achsel  Valentina Romeo  Giuseppe Lamorte  Donatella Biancolini  Francesca Cordero  Alessia Maracchioni  Silvia C Lenzken  MariaTeresa Carrì  Silvia Barabino  Remo Sanges  Davide Bonanno  Raffaele A Calogero  R A Calogero  Francesca Zolezzi 

PROVIDER: E-GEOD-21298 | ArrayExpress | 2010-12-22

SECONDARY ACCESSION(S): GSE21298PRJNA129447

REPOSITORIES: GEO, ArrayExpress

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Publications


Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders including Parkinson, Alzheimer, and Amyotrophic Lateral Sclerosis (ALS). In addition, aberrant mRNA splicing has been documented in neurodegeneration. To characterize the cellular response to mitochondrial perturbations at the level of gene expression and alternative pre-mRNA splicing we used splicing-sensitive microarrays to profile human neuroblastoma SH-SY5Y cells treated with paraquat  ...[more]

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