Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mauro Cozzolino Tilmann Achsel Valentina Romeo Giuseppe Lamorte Donatella Biancolini Francesca Cordero Alessia Maracchioni Silvia C Lenzken MariaTeresa Carrì Silvia Barabino Remo Sanges Davide Bonanno Raffaele A Calogero R A Calogero Francesca Zolezzi
PROVIDER: E-GEOD-21298 | ArrayExpress | 2010-12-22
SECONDARY ACCESSION(S): GSE21298PRJNA129447
REPOSITORIES: GEO, ArrayExpress
Lenzken Silvia C SC Romeo Valentina V Zolezzi Francesca F Cordero Francesca F Lamorte Giuseppe G Bonanno Davide D Biancolini Donatella D Cozzolino Mauro M Pesaresi Maria Grazia MG Maracchioni Alessia A Sanges Remo R Achsel Tilmann T Carrì Maria Teresa MT Calogero Raffaele A RA Barabino Silvia M L SM
Human mutation 20110125 2
Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders including Parkinson, Alzheimer, and Amyotrophic Lateral Sclerosis (ALS). In addition, aberrant mRNA splicing has been documented in neurodegeneration. To characterize the cellular response to mitochondrial perturbations at the level of gene expression and alternative pre-mRNA splicing we used splicing-sensitive microarrays to profile human neuroblastoma SH-SY5Y cells treated with paraquat ...[more]