Transcriptomics

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Profiling neuroblastoma SH-SY5Y with Paraquat treatment


ABSTRACT: Human SH-SY5Y neuroblastoma cells treated with paraquat, a neurotoxic herbicide which both catalyzes the formation of reactive oxygen species (ROS) and induces mitochondrial damage in animal models was profiled using Affimetrix Exon 1.0 ST GeneChips® Human SH-SY5Y neuroblastoma cells was compared with respect to Human SH-SY5Y neuroblastoma cells treated with Paraquat. Parqaut treatment was done as described by Maracchioni, A., Totaro, A., Angelini, D.F., Di Penta, A., Bernardi, G., Carri, M.T., and Achsel, T. (2007) J Neurochem 100, 142-153

ORGANISM(S): Homo sapiens  

SUBMITTER: Mauro Cozzolino   Tilmann Achsel  Valentina Romeo  Giuseppe Lamorte  Donatella Biancolini  Alessia Maracchioni  Silvia C Lenzken  MariaTeresa Carrì  Silvia Barabino  Remo Sanges  Davide Bonanno  Raffaele A Calogero  Francesca Zolezzi 

PROVIDER: E-GEOD-21305 | ArrayExpress | 2010-12-22

SECONDARY ACCESSION(S): GSE21305PRJNA129435

REPOSITORIES: GEO, ArrayExpress

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Publications


Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders including Parkinson, Alzheimer, and Amyotrophic Lateral Sclerosis (ALS). In addition, aberrant mRNA splicing has been documented in neurodegeneration. To characterize the cellular response to mitochondrial perturbations at the level of gene expression and alternative pre-mRNA splicing we used splicing-sensitive microarrays to profile human neuroblastoma SH-SY5Y cells treated with paraquat  ...[more]

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