Dataset Information


Profiling neuroblastoma SH-SY5Y with Paraquat treatment

ABSTRACT: Human SH-SY5Y neuroblastoma cells treated with paraquat, a neurotoxic herbicide which both catalyzes the formation of reactive oxygen species (ROS) and induces mitochondrial damage in animal models was profiled using Affimetrix Exon 1.0 ST GeneChips® Human SH-SY5Y neuroblastoma cells was compared with respect to Human SH-SY5Y neuroblastoma cells treated with Paraquat. Parqaut treatment was done as described by Maracchioni, A., Totaro, A., Angelini, D.F., Di Penta, A., Bernardi, G., Carri, M.T., and Achsel, T. (2007) J Neurochem 100, 142-153

ORGANISM(S): Homo sapiens  

SUBMITTER: Mauro Cozzolino  Tilmann Achsel   Valentina Romeo   Giuseppe Lamorte   Donatella Biancolini   Alessia Maracchioni   Silvia C Lenzken   MariaTeresa Carrì   Silvia Barabino   Remo Sanges   Davide Bonanno   Raffaele A Calogero   Francesca Zolezzi    

PROVIDER: E-GEOD-21305 | ArrayExpress | 2012-03-27



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Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders including Parkinson, Alzheimer, and Amyotrophic Lateral Sclerosis (ALS). In addition, aberrant mRNA splicing has been documented in neurodegeneration. To characterize the cellular response to mitochondrial perturbations at the level of gene expression and alternative pre-mRNA splicing we used splicing-sensitive microarrays to profile human neuroblastoma SH-SY5Y cells treated with paraquat  ...[more]

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