Genomics

Dataset Information

302

Epigenomic profiling of 3T3-L1 adipogenesis


ABSTRACT: 3T3-L1 pre-adipocyte cells were grown to confluence and induced to differentiate in adipogenic media. Examination of 6 histone modifications and CTCF at 4 time points and PPARG at 1 time point using ChIP-Seq

ORGANISM(S): Mus musculus  

SUBMITTER: Tarjei S Mikkelsen   Zhao Xu  Jeffrey M Gimble  Evan D Rosen  Eric S Lander 

PROVIDER: E-GEOD-21365 | ArrayExpress | 2010-09-30

SECONDARY ACCESSION(S): SRP002337GSE21365PRJNA126097

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Comparative epigenomic analysis of murine and human adipogenesis.

Mikkelsen Tarjei S TS   Xu Zhao Z   Zhang Xiaolan X   Wang Li L   Gimble Jeffrey M JM   Lander Eric S ES   Rosen Evan D ED  

Cell 20101001 1


We report the generation and comparative analysis of genome-wide chromatin state maps, PPARγ and CTCF localization maps, and gene expression profiles from murine and human models of adipogenesis. The data provide high-resolution views of chromatin remodeling during cellular differentiation and allow identification of thousands of putative preadipocyte- and adipocyte-specific cis-regulatory elements based on dynamic chromatin signatures. We find that the specific locations of most such elements d  ...[more]

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