Dataset Information


Array CGH between GK and Wistar Rats for Detecting Copy Number Variations

ABSTRACT: The Goto-Kakizak (GK) rat, a nonobese animal model of Type 2 diabetes (T2D), were developed by repeated inbreeding of glucose-intolerent individuals selected from Wistar rats. During their development, GK rats suffer from reduced beta-cell mass and insulin resistance spontaneously (T2D phenotype), which are supposed to be caused by loci holding different genotypes between GK and Wistar rats. This array CGH experiment can detect loci which show different copy numbers (genotype) between GK and Wistar rats. These loci serve as a valuable repository for mining candidates contributing to the pathogenesis of T2D. The genomic DNA taken from 3 male GK rats as 3 test samples while pooled genomic DNA from 8 male Wistar rats as the common referrence. For each of the hybridization, a dye-swap was designed as well.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Yuan-Yuan Li   Rong-Xia Li  Yang Yu  Zhi-Qiang Ye  Shen Niu 

PROVIDER: E-GEOD-21387 | ArrayExpress | 2010-12-31



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Analyses of copy number variation of GK rat reveal new putative type 2 diabetes susceptibility loci.

Ye Zhi-Qiang ZQ   Niu Shen S   Yu Yang Y   Yu Hui H   Liu Bao-Hong BH   Li Rong-Xia RX   Xiao Hua-Sheng HS   Zeng Rong R   Li Yi-Xue YX   Wu Jia-Rui JR   Li Yuan-Yuan YY  

PloS one 20101123 11

Large efforts have been taken to search for genes responsible for type 2 diabetes (T2D), but have resulted in only about 20 in humans due to its complexity and heterogeneity. The GK rat, a spontanous T2D model, offers us a superior opportunity to search for more diabetic genes. Utilizing array comparative genome hybridization (aCGH) technology, we identifed 137 non-redundant copy number variation (CNV) regions from the GK rats when using normal Wistar rats as control. These CNV regions (CNVRs) c  ...[more]

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