Dataset Information


Regulation of human skin pigmentation in situ by repetitive UV exposure - Molecular characterization of responses to UVA, UVB and SSR

ABSTRACT: To test the hypothesis that different mechanisms and/or factors might be involved in physiological pigmentary responses of the skin to different types of UV, we used whole human genome microarrays and immunohistochemical analyses to characterize human skin in situ to examine how melanocyte-specific proteins and paracrine melanogenic factors are regulated by repetitive exposure to suberythemal doses of different types of UV (UVA, UVB or SSR). Six volunteers with skin type II-III were irradiated with SSR, UVA or UVB radiation for 2 weeks (5 times per week, 10 times total) after preliminary determination of their MEDs. Biopsies were taken 3 days after the last irradiation.

ORGANISM(S): Homo sapiens  

SUBMITTER: Vincent Hearing   Vincent J Hearing  Wonseon Choi 

PROVIDER: E-GEOD-21429 | ArrayExpress | 2010-08-18



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Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB.

Choi Wonseon W   Miyamura Yoshinori Y   Wolber Rainer R   Smuda Christoph C   Reinhold William W   Liu Hongfang H   Kolbe Ludger L   Hearing Vincent J VJ  

The Journal of investigative dermatology 20100211 6

UV radiation is a major environmental factor that affects pigmentation in human skin and can eventually result in various types of UV-induced skin cancers. The effects of various wavelengths of UV on melanocytes and other types of skin cells in culture have been studied, but little is known about gene expression patterns in situ following in situ exposure of human skin to different types of UV (UVA and/or UVB). Paracrine factors expressed by keratinocytes and/or fibroblasts that affect skin pigm  ...[more]

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