Transcriptomics

Dataset Information

30

Initial analysis of copy number variations in cattle selected for resistance or susceptibility to intestinal nematodes


ABSTRACT: Here we describe the initial analysis of copy number variations in cattle selected for resistance or susceptibility to intestinal nematodes The custom aCGH chips that interrogated the whole genome CNVs were build for 3 pairs of contemporary parasite-susceptible and resistant Angus.

ORGANISM(S): Bos taurus  

SUBMITTER: Mario Ventura  Yali Hou   Ratan K Choudhary   Jessica Shaffer   George E Liu   Deborah A Hebert   Louis C Gasbarre   Erin E Connor   Chinwendu Amazu   Twain Brown   George Liu   Maria F Cardone    

PROVIDER: E-GEOD-21538 | ArrayExpress| 2014-05-01

SECONDARY ACCESSION(S): GSE21538PRJNA126197

REPOSITORIES: GEO, ArrayExpress

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Publications

Initial analysis of copy number variations in cattle selected for resistance or susceptibility to intestinal nematodes.

Liu George E GE   Brown Twain T   Hebert Deborah A DA   Cardone Maria Francesca MF   Hou Yali Y   Choudhary Ratan K RK   Shaffer Jessica J   Amazu Chinwendu C   Connor Erin E EE   Ventura Mario M   Gasbarre Louis C LC  

Mammalian genome : official journal of the International Mammalian Genome Society 20101203 1-2


Genomic structural variation is an important and abundant source of genetic and phenotypic variation. We report an initial analysis of copy number variations (CNVs) in cattle selected for resistance or susceptibility to intestinal nematodes. We performed three array comparative genomic hybridization (CGH) experiments to compare Angus cattle with extreme phenotypes for fecal egg count and serum pepsinogen level. We identified 20 CNVs in total, of which 12 were within known chromosomes harboring o  ...[more]

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