Transcriptomics

Dataset Information

5

Expression profiling of murine neonatal lung tissue from Carm1 knockouts and wild type controls


ABSTRACT: Coactivator associated arginine methyltransferase I (CARM1, also known as Protein aRginine MethylTransferase 4, or PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are smaller than their littermates, fail to breath, and die shortly after birth, demonstrating the critical role of CARM1 in development.We performed gene expression analysis to identify genes that are responsible for hyperproliferaion in CARM1 knockout lung. RNA extracted from murine lung at E18.5 with carm1 knockouts and wild type controls was hybridised to Affymetrix mouse430.2 GeneChips to identify differentially expressed genes in the disease state.

ORGANISM(S): Mus musculus  

SUBMITTER: Natasha J Sng   Annalisa DiRuscio  Balázs Halmos  Neelu Yadav  Mark T Bedford  Scott J Rodig  Elena Levantini  Ulrich Steidl  Alexander Ebralidze  Susumu Kobayashi  BIDMC Genomics  Meritxell Alberich-Jordà  Tyler Caron  Manoj Bhasin  Daehoon Kim  Gang Huang  Daniel G Tenen  Olivier Kocher  Karen B O'Brien 

PROVIDER: E-GEOD-21606 | ArrayExpress | 2010-07-07

SECONDARY ACCESSION(S): GSE21606PRJNA126977

REPOSITORIES: GEO, ArrayExpress

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Publications


Coactivator-associated arginine methyltransferase I (CARM1; PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are small, fail to breathe and die shortly after birth, demonstrating the crucial role of CARM1 in development. In adults, CARM1 is overexpressed in human grade-III breast tumors and prostate adenocarcinomas, and knockdown of CARM1 inhibits proliferation of breast and prostate c  ...[more]

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