Transcriptomics

Dataset Information

0

Expression profiling of murine neonatal lung tissue from Carm1 knockouts and wild type controls


ABSTRACT: Coactivator associated arginine methyltransferase I (CARM1, also known as Protein aRginine MethylTransferase 4, or PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are smaller than their littermates, fail to breath, and die shortly after birth, demonstrating the critical role of CARM1 in development.We performed gene expression analysis to identify genes that are responsible for hyperproliferaion in CARM1 knockout lung. RNA extracted from murine lung at E18.5 with carm1 knockouts and wild type controls was hybridised to Affymetrix mouse430.2 GeneChips to identify differentially expressed genes in the disease state.

ORGANISM(S): Mus musculus  

SUBMITTER: Natasha J Sng  Annalisa DiRuscio   Balázs Halmos   Neelu Yadav   Mark T Bedford   Scott J Rodig   Elena Levantini   Ulrich Steidl   Alexander Ebralidze   Susumu Kobayashi   BIDMC Genomics   Meritxell Alberich-Jordà   Tyler Caron   Manoj Bhasin   Daehoon Kim   Gang Huang   Daniel G Tenen   Olivier Kocher   Karen B O'Brien    

PROVIDER: E-GEOD-21606 | ArrayExpress | 2010-07-07

SECONDARY ACCESSION(S): GSE21606PRJNA126977

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications


Coactivator-associated arginine methyltransferase I (CARM1; PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are small, fail to breathe and die shortly after birth, demonstrating the crucial role of CARM1 in development. In adults, CARM1 is overexpressed in human grade-III breast tumors and prostate adenocarcinomas, and knockdown of CARM1 inhibits proliferation of breast and prostate c  ...[more]

Similar Datasets

2010-07-07 | GSE21606 | GEO
2011-06-01 | E-GEOD-26454 | ArrayExpress
2011-06-01 | E-GEOD-26259 | ArrayExpress
2011-06-01 | GSE26454 | GEO
| GSE95644 | GEO
| GSE95643 | GEO
| GSE72901 | GEO
2011-06-01 | GSE26259 | GEO
2015-08-12 | E-GEOD-26259 | ExpressionAtlas
2017-07-03 | PXD005871 | Pride