Dataset Information


Affymetrix SNP array data for 31 Tibetan samples

ABSTRACT: This data was used to identify regions of the genome that have undergone positive selection in a high-altitude Tibetan population. Affymetrix SNP arrays were used to genotype DNA extracted from blood samples. This data was used to perform genome-wide scans of positive selection in a native high-altitude Tibetan population.

ORGANISM(S): Homo sapiens  

SUBMITTER: Lynn B Jorde   Rili Ge  Josef T Prchal  T Simonson 

PROVIDER: E-GEOD-21661 | ArrayExpress | 2010-07-22



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Tibetans have lived at very high altitudes for thousands of years, and they have a distinctive suite of physiological traits that enable them to tolerate environmental hypoxia. These phenotypes are clearly the result of adaptation to this environment, but their genetic basis remains unknown. We report genome-wide scans that reveal positive selection in several regions that contain genes whose products are likely involved in high-altitude adaptation. Positively selected haplotypes of EGLN1 and PP  ...[more]

Publication: 1/2

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