Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: W Ouyang Weiming Ouyang M O Li
PROVIDER: E-GEOD-21678 | ArrayExpress | 2010-09-13
SECONDARY ACCESSION(S): GSE21678PRJNA125833
REPOSITORIES: GEO, ArrayExpress
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E-GEOD-21678.README.txt | Txt | ||
E-GEOD-21678.eSet.r | Other | ||
E-GEOD-21678.idf.txt | Idf | ||
E-GEOD-21678.processed.1.zip | Processed | ||
E-GEOD-21678.raw.1.zip | Raw |
Ouyang Weiming W Beckett Omar O Ma Qian Q Paik Ji-hye JH DePinho Ronald A RA Li Ming O MO
Nature immunology 20100513 7
CD4(+) regulatory T cells (T(reg) cells) characterized by expression of the transcription factor Foxp3 have a pivotal role in maintaining immunological tolerance. Here we show that mice with T cell-specific deletion of both the Foxo1 and Foxo3 transcription factors (collectively called 'Foxo proteins' here) developed a fatal multifocal inflammatory disorder due in part to T(reg) cell defects. Foxo proteins functioned in a T(reg) cell-intrinsic manner to regulate thymic and transforming growth fa ...[more]