Transcriptomics

Dataset Information

66

Foxo1/3-deficient Treg cells


ABSTRACT: Identification of Foxos target genes in Treg cells. Foxo1and Foxo3 are transcription factors of Foxo family. CD4+Foxp3+ Treg cells isolated from wild-type and Foxo1/3-deficient mice were analyzed by global gene expression profiling. Results indicate Foxos regulate expression of a subset of Treg cell signature genes and genes in control of T cell homeostasis, signaling and metabolism. 2 sets wild-type and Foxo1/3-deficient CD4+Foxp3+ Treg cells

ORGANISM(S): Mus musculus  

SUBMITTER: W Ouyang   Weiming Ouyang  M O Li 

PROVIDER: E-GEOD-21678 | ArrayExpress | 2010-09-13

SECONDARY ACCESSION(S): GSE21678PRJNA125833

REPOSITORIES: GEO, ArrayExpress

Dataset's files

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E-GEOD-21678.README.txt Txt
E-GEOD-21678.eSet.r Other
E-GEOD-21678.idf.txt Idf
E-GEOD-21678.processed.1.zip Processed
E-GEOD-21678.raw.1.zip Raw
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Publications

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

Ouyang Weiming W   Beckett Omar O   Ma Qian Q   Paik Ji-hye JH   DePinho Ronald A RA   Li Ming O MO  

Nature immunology 20100513 7


CD4(+) regulatory T cells (T(reg) cells) characterized by expression of the transcription factor Foxp3 have a pivotal role in maintaining immunological tolerance. Here we show that mice with T cell-specific deletion of both the Foxo1 and Foxo3 transcription factors (collectively called 'Foxo proteins' here) developed a fatal multifocal inflammatory disorder due in part to T(reg) cell defects. Foxo proteins functioned in a T(reg) cell-intrinsic manner to regulate thymic and transforming growth fa  ...[more]

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