Dataset Information


Foxo1/3-deficient Treg cells

ABSTRACT: Identification of Foxos target genes in Treg cells. Foxo1and Foxo3 are transcription factors of Foxo family. CD4+Foxp3+ Treg cells isolated from wild-type and Foxo1/3-deficient mice were analyzed by global gene expression profiling. Results indicate Foxos regulate expression of a subset of Treg cell signature genes and genes in control of T cell homeostasis, signaling and metabolism. 2 sets wild-type and Foxo1/3-deficient CD4+Foxp3+ Treg cells

ORGANISM(S): Mus musculus  

SUBMITTER: W Ouyang   Weiming Ouyang  M O Li 

PROVIDER: E-GEOD-21678 | ArrayExpress | 2010-09-13



Dataset's files

E-GEOD-21678.README.txt Txt
E-GEOD-21678.eSet.r Other
E-GEOD-21678.idf.txt Idf Processed Raw
Items per page:
1 - 5 of 6
altmetric image


Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

Ouyang Weiming W   Beckett Omar O   Ma Qian Q   Paik Ji-hye JH   DePinho Ronald A RA   Li Ming O MO  

Nature immunology 20100513 7

CD4(+) regulatory T cells (T(reg) cells) characterized by expression of the transcription factor Foxp3 have a pivotal role in maintaining immunological tolerance. Here we show that mice with T cell-specific deletion of both the Foxo1 and Foxo3 transcription factors (collectively called 'Foxo proteins' here) developed a fatal multifocal inflammatory disorder due in part to T(reg) cell defects. Foxo proteins functioned in a T(reg) cell-intrinsic manner to regulate thymic and transforming growth fa  ...[more]

Similar Datasets

2010-09-13 | GSE21678 | GEO
1000-01-01 | S-EPMC4845935 | BioStudies
2011-01-01 | S-EPMC3163967 | BioStudies
2011-10-21 | GSE23926 | GEO
2011-10-20 | E-GEOD-23926 | ArrayExpress
2012-09-07 | E-GEOD-40656 | ArrayExpress
2010-01-01 | S-EPMC3034255 | BioStudies
2014-01-01 | S-EPMC4185926 | BioStudies
2012-09-07 | E-GEOD-40655 | ArrayExpress
| GSE40655 | GEO