Transcriptomics

Dataset Information

4

Gene expression profile in three regions of the hippocampus of middle aged and old rats exposed to dietary restriction


ABSTRACT: Aging is associated with a decline in hippocampal mediated learning and memory, a process which can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction. Old rats were determined to be good performers (GP) or poor performers (PP) in behavioural tests to assess their hippocampal function. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction.

REANALYSED by: E-GEOD-21681

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Thomas C Foster   Zane Zeier 

PROVIDER: E-GEOD-21681 | ArrayExpress | 2010-06-08

SECONDARY ACCESSION(S): GSE21681PRJNA125839

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene expression in the hippocampus: regionally specific effects of aging and caloric restriction.

Zeier Zane Z   Madorsky Irina I   Xu Ying Y   Ogle William O WO   Notterpek Lucia L   Foster Thomas C TC  

Mechanisms of ageing and development 20101103 1-2


We measured changes in gene expression, induced by aging and caloric restriction (CR), in three hippocampal subregions. When analysis included all regions, aging was associated with expression of genes linked to mitochondrial dysfunction, inflammation, and stress responses, and in some cases, expression was reversed by CR. An age-related increase in ubiquintination was observed, including increased expression of ubiquitin conjugating enzyme genes and cytosolic ubiquitin immunoreactivity. CR decr  ...[more]

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